Genetic determinants of response to cardiovascular drugs
نویسندگان
چکیده
منابع مشابه
Genetic determinants of response to clopidogrel and cardiovascular events.
BACKGROUND Pharmacogenetic determinants of the response of patients to clopidogrel contribute to variability in the biologic antiplatelet activity of the drug. The effect of these determinants on clinical outcomes after an acute myocardial infarction is unknown. METHODS We consecutively enrolled 2208 patients presenting with an acute myocardial infarction in a nationwide French registry and r...
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Individual heterogeneity in responsiveness to antiplatelet agents may be due to either inherited or acquired factors. These potential variables include genetic polymorphisms in platelet proteins targeted by the drugs, differences in their pharmacokinetics, drug or other environmental interactions, and the baseline state of platelet function before initiation of treatment. With regard to the lat...
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ژورنال
عنوان ژورنال: Current Opinion in Cardiology
سال: 2012
ISSN: 0268-4705
DOI: 10.1097/hco.0b013e32835220e3